RDS

Prolonged Glucocorticoid Treatment in Acute Lung Injury
In acute respiratory distress syndrome (ARDS), the evolution of systemic and pulmonary inflammation in the first week of mechanical ventilation determines the physiological progression (resolving versus unresolving) and outcome of the disease. Innate or treatment-induced downregulation of systemic inflammation is the condition sine qua non to resolution of sepsis and ARDS.

Surfactant Therapy
It is well known that surfactant therapy can be used to reduce the risk of respiratory distress syndrome (RDS) in premature babies (prophylactic therapy) or to treat already established RDS (rescue therapy). in general.

Inhaled Nitric Oxide in the Treatment of Persistent Pulmonary Hypertension in the Newborn—An Update
Persistent pulmonary hypertension of the newborn (PPHN), also known as persistent fetal circulation, was first described by Gersony in 1969 as a neonatal condition characterized by cyanosis and hypoxemia.

Understanding the role VEGF plays in ARDS consequently provides an ideal opportunity to discover new therapies for ARDS.

• Vascular endothelial growth factor and related molecules in acute lung injury
• VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema
• Vascular endothelial growth factor gene polymorphism and acute respiratory distress syndrome
• Decreased VEGF concentration in lung tissue and vascular injury during ARDS
• Vascular endothelial growth factor may contribute to increased vascular permeability in acute respiratory distress syndrome

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a severe lung condition that causes respiratory failure. Individuals with ALI/ARDS often require the use of a respirator or artificial breathing machine, known as a mechanical ventilator, while in an intensive care unit (ICU).

• Mechanical ventilation induces inflammation, lung injury, and extra-pulmonary organ dysfunction in experimental pneumonia
• Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome
• Differential effects of mechanical ventilatory strategy on lung injury and systemic organ inflammation in mice
• Mechanical ventilation exacerbates alveolar macrophage dysfunction in the lungs of ethanol-fed rats
• Modulation of lipopolysaccharide-induced gene transcription and promotion of lung injury by mechanical ventilation

This study is designed to exam the effects of early management with high frequency percussive ventilation (HFPV) on patients with lung injury. Patients at risk for Acute Respiratory Distress Syndrome (ARDS) will be enrolled and randomized to one of two groups. One group will be managed with HFPV.

• High-frequency percussive ventilation: an alternative mode of ventilation for head-injured patients with adult respiratory distress syndrome
• High-frequency percussive ventilation as a salvage modality in adult respiratory distress syndrome: a preliminary study
• High-frequency percussive ventilation improves oxygenation in patients with ARDS
• Prone positioning of pediatric patients with ARDS results in improvement in oxygenation if maintained > 12 h daily
• High frequency oscillatory ventilation in burn patients with the acute respiratory distress syndrome